Years Ago Human Brains Changed Forever

Like treasured recipes passed down from generation to generation, there are just some regions of DNA that evolution doesn't dare tweak. Mammals far and wide share a variety of such encoded sequences, for example, which have remained untouched for millions of years.


Humans are a strange exception to this club. For some reason, recipes long preserved by our ancient ancestors were suddenly 'spiced up' within a short evolutionary period of time.

Because we're the only species in which these regions have been rewritten so rapidly, they are called 'human accelerated regions' (or HARs). What's more, scientists think at least some HARs could be behind many of the qualities that set humans apart from their close relatives, like chimpanzees and bonobos.

Led by computational biologist Katie Pollard, director of the Gladstone Institute of Data Science and Biotechnology in the US, a team of researchers identified HARs nearly two decades ago while comparing human and chimpanzee genomes.

In a new study, Pollard's team found the 3D folding of human DNA in the nucleus is a key factor in this pivotal moment for our species.


Imagine a length of DNA from our last common ancestor with chimpanzees as a long scarf wrapped around your neck, with stripes of various colors running across its weave down its entire length.

Now picture someone tried to make the exact same scarf, but they didn't quite follow the original pattern. Some of the stripes are narrower, some are wider, and some feature colors in a different order than the original.  READ MORE...

Searching for Missing Genomes

Enormous strides have been made to unravel the secrets of the human genome, so why are we missing the genetic information of most of the planet?

In the summer of 2020, a 63-year-old African American woman with colon cancer was treated with a common chemotherapy known as fluoropyrimidines at the National Institutes of Health (NIH) Clinical Centre in Bethesda, Maryland. But over the coming weeks, she began to develop a severe side-effect known as pancytopenia – a rapid and sudden decrease of red and white blood cells and platelets – causing her to be rushed into intensive care.

This kind of reaction is surprisingly common. Around 38,000 cancer patients in England and approximately 154,000 patients in the US are initiated on fluoropyrimidine-based treatments every year. While fluoropyrimidines help save lives, between 20% and 30% of the people who receive these drugs require lower doses, because their bodies struggle to process them. If given the standard dose, they experience reactions which can vary from severe to fatal.

Like many adverse drug reactions, this is thought to be at least in part due to variations in the human genome, the strings of billions of letters or chemical bases which comprise our DNA. But while all humans share 99.9% of our genome, the remaining 0.1% varies markedly from one individual to another, or between ethnic groups. Differences in the underlying sequence behind a particular gene – which can be anything from a few hundred to several million bases – can have profound and far-reaching consequences for our health.

In recent years, genetic-sequencing studies have started to get to the bottom of why some people react so badly to fluoropyrimidines, pinpointing four different variations of a gene called DPYD which is involved in metabolism, as the likely cause. Healthcare systems around the world have now begun sequencing the DNA of certain cancer patients and screening for each of these four variants before determining their chemotherapy dose.

The only problem is that these studies were done entirely on white people, or as geneticists say, "individuals of European ancestry". While different variants of DPYD may serve as warning signs for people of other ethnicities, we do not have enough data to be sure of which variants are most applicable to different ethnic groups. "Ethnic minority patients will usually be given conventional doses of the drugs," says Munir Pirmohamed, a pharmacologist at the University of Liverpool in the UK. "Some of these patients will carry other ethnic-specific variants which also affect their ability to metabolise these drugs, but we do not currently genotype for those, largely because we do not know."  READ MORE...

Genetic Mutations Found

A woman developed 12 tumors — seven benign and five cancerous — before her 40th birthday. Medical researchers recently discovered why she's so prone to the abnormal growths: She carries a set of genetic mutations never seen before in humans.

The woman, now 36 years old, carries two mutant copies of a gene called MAD1L1, one from each parent, according to a new report, published Wednesday (Nov. 2) in the journal Science Advances(opens in new tab). The gene codes for a protein called MAD1, which fulfills a crucial role in cell division.

When one cell splits into two, it first duplicates all its DNA and then packages the genetic material into compact structures called chromosomes. The chromosomes then line up neatly along the cell's midline and get yanked in half; that way, when the mother cell splits in two, half of the DNA ends up in each daughter cell. 

The MAD1 protein helps ensure that the chromosomes line up correctly during this process, so all cells end up with the usual 23 pairs of chromosomes, according to UniProt(opens in new tab), a database of protein sequence and functional information.  READ MORE...

Myth Versus Reality on Aging

Paying extra for exotic vitamins in skin creams that promise to erase fine lines and prevent wrinkles will get you little more than an empty wallet, according to dermatologists. Although many face creams contain vitamins known as antioxidants, very few are actually effective in preventing or reversing skin damage.

"Despite advertising claims, almost all available topical formulations contain very low concentrations of antioxidants that are not well absorbed by the skin," said Karen E. Burke, MD, in a presentation to the American Academy of Dermatology's annual meeting this week in New Orleans. "There are three antioxidants that have been proven to decrease the effect of the sun on the skin and actually prevent further damage: selenium, vitamin E, and vitamin C."

Antioxidants are known to prevent agents called free radicals from damaging cells in the body and the skin. Free radicals are a result of normal body processes, but they can also be created by exposure to various environmental factors such as smoking or ultraviolet (UV) radiation from the sun and can speed up the aging process.  READ MORE...

Code to Reverse Aging

PARIS — Barbra Streisand loved her dog Samantha, aka Sammy. The white and fluffy purebred Coton of Tulear was even present on the steps of the Elysée Palace, the French President’s official residence, when Streisand received the Legion of Honor in 2007.

As the singer and actress explained inThe New York Times in 2018, she loved Sammy so much that, unable to bring herself to see her pass away, she had the dog cloned by a Texas firm for the modest sum of 50,000 dollars just before she died in 2017, at the age of 14. And that's how Barbra Streisand became the happy owner of Miss Violet and Miss Scarlet, two puppies who are the spitting image of the deceased Samantha.

This may sound like a joke, but there is one deeply disturbing fact that Harvard Medical School genetics professor David A. Sinclair points out in his book Why We Age – And Why We Don’t Have To. It is that the cloning of an old dog has led to two young puppies.

This proves that DNA — ours as well as that of Sammy — has everything it takes to restore lost youth. This is a property that could be used to "reverse" aging without having to go through the problematic stage of cloning.  READ MORE...

DNA Rewrites History

The origin of Assateague’s wild horses has remained a mystery for centuries, but new genetic data supports the theory that they descended from Spanish horses marooned on the barrier island. Credit: Florida Museum photo by Jeff Gage

Ancient DNA from an American domesticated horse lends credence to shipwreck folklore.

An abandoned Caribbean colony discovered centuries later and a case of mistaken identity in the archaeological record have colluded to rewrite the history of a barrier island off the shores of Virginia and Maryland.

When Nicolas Delsol, a postdoctoral researcher at the Florida Museum of Natural History, set out to analyze ancient DNA recovered from cow bones discovered in archaeological sites, these seemingly unrelated threads were woven together. 

Delsol wanted to know how cattle were domesticated in the Americas, and he discovered the answer in the genetic information preserved in centuries-old teeth. However, they also held a surprise.  READ MORE...

Superconductors That Transform Technology

Could let computers work at warp speed, save energy, and even make trains fly?

Scientists have used DNA to overcome a nearly insurmountable obstacle to engineering materials that will revolutionize electronics. Published in the journal Science on July 28, the work was performed by researchers at the University of Virginia School of Medicine and their collaborators.

One possible outcome of these engineered materials could be superconductors, which have zero electrical resistance, allowing electrons to flow unimpeded. That means that, unlike current means of electrical transmission, they don’t lose energy and don’t create heat. 

Development of a superconductor that could be used widely at normal pressures and room temperature – instead of at extremely high or low temperatures, as is now possible – could lead to many technological wonders. These include hyper-fast computers, shrinking the size of electronic devices, allowing high-speed trains to float on magnets and slash energy use, and many more.

One such superconductor was first proposed by Stanford physicist William A. Little more than 50 years ago. Scientists have spent decades trying to make it work. However, even after validating the feasibility of his idea, they were left with a challenge that appeared impossible to overcome. Until now.

Edward H. Egelman, PhD, of UVA’s Department of Biochemistry and Molecular Genetics, has been a leader in the field of cryo-electron microscopy (cryo-EM), and he and Leticia Beltran, a graduate student in his lab, used cryo-EM imaging for this seemingly impossible project. “It demonstrates,” he said, “that the cryo-EM technique has great potential in materials research.”  READ MORE...

We Were Ocean Dwellers in Early Life

By studying the genetic tree of life, scientists have determined that the first life on Earth may have lived underwater, where it would be shielded from harmful ultraviolet light from the sun.

The origin of life on Earth remains a mystery, but scientists are slowly putting together genetic puzzle pieces to learn more about how the first life on Earth lived, between 2.5 and 4 billion years ago. Now, scientists from the University of Wisconsin-Madison and the University of California, Riverside, have used machine learning to trace the evolutionary development of a protein-based molecule called rhodopsin back to some of the most ancient microbial life-forms to have existed on Earth. The results may also inform the search for life beyond Earth, the scientists argue.

"It's like taking the DNA of many grandchildren to reproduce the DNA of their grandparents," astrobiologist Edward Schwieterman of the University of California Riverside, a co-author on the new research, said in a statement(opens in new tab).

The researchers suspect that rhodopsin provided the battery power for early life, turning light from the sun into energy. On modern Earth, rhodopsin can absorb blue, green, yellow and orange light. (It is also tangentially related to the light-absorbing rods and cones that our eyes use to see the world.)

Schwieterman and his colleagues began by using machine learning to look for the genes that control rhodopsin in as wide a swathe of life on Earth as possible, then identifying those genes that had the longest lineages.

This analysis suggested that ancient rhodopsin absorbed just blue and green light. This reduced capability makes sense in a scenario in which early life may have originated in the ocean, where blue and green wavelengths of light penetrate deeper into a column of water than other optical wavelengths: Being able to absorb these wavelengths to derive energy would have been vitally important.  READ MORE...

The Founding Population of Mexico

Archaeologists have recovered DNA from 10 colonial-era inhabitants of Campeche, Mexico, revealing the diversity of the founding populations of European settlements in the Americas.

Campeche was an early colonial settlement in Yucatán. It was founded in 1540, less than 20 years after the Spanish conquest of the Aztecs, once conquistadors secured their rule.

The important port was initially served by a parish church until it was replaced by a cathedral in 1680. The church was rediscovered in 2000 during rescue excavations when archaeologists found 129 early colonial burials at the site.

Early attempts to extract DNA from these burials failed. Now advances in aDNA research have allowed Professor Vera Tiesler and a team of researchers from Harvard University to gather genetic data from this important site. Their work is published in the journal Antiquity.

“Ancient DNA methods have improved to the point where we can generate robust data from warm, humid environments,” said Dr Jakob Sedig, from the Reich Laboratory at Harvard University and co-lead author of the research, “Using the petrous bone, we were able to generate excellent data from all 10 individuals we tested, which is encouraging for future ancient DNA analysis in this region.”

The aDNA revealed the 10 individuals interred in the colonial cemetery were made up of six females and four males, and none were close relatives. Most were local Indigenous Americans, but people of European and sub-Saharan African ancestry were also identified. READ MORE...

The Science of Aliens

All cellular life on Earth is based on DNA, which transfers information—about everything from hair color to personality traits—from one generation to the next. The four chemical bases that convey this information are adenine (A), cytosine (C), guanine (G), and thymine (T).

The other essential “information molecule” on Earth is RNA, in which thymine (T) is replaced by uracil (U). RNA has a one-string structure rather than a double-string structure like DNA. 

The first cellular life on our planet is thought to have relied exclusively on this means of transferring genetic information—in the so-called “RNA world”—and even today there are viruses (like the one that causes COVID) that only use RNA.

In a paper recently published in Science, a research group led by Dona Sleiman from the Institute Pasteur in Paris has discovered that some viruses show more variation in their genetic coding than was previously known. In the RNA of these viruses, adenine (A) is replaced with Z, where Z stands for diaminopurine.

This follows an earlier study by Zunyi Yang and colleagues at the Foundation for Applied Molecular Evolution in Gainesville, Florida, showing that an artificial genetic system could be created by adding two additional non-standard bases to ordinary DNA. 

Amazingly, the artificial six-base system continued to evolve rather than reverting back to the natural four-base system. This implies that the DNA we take as standard—made of A, C, G, and T—is just one of many viable solutions to the challenge of biological information transfer.

The variability does not stop here. Strings of DNA are organized in base triplets that determine which of the standard 20 amino acids are assigned to synthesize proteins. However, these triplet assignments are not universal. 

For example, CUG, which usually codes for the amino acid serine, instead codes for the amino acid leucine in some types of fungi. Also, some organisms naturally encode for two additional amino acids instead of the standard 20 amino acids.  READ MORE...

They Are The Borg

In the TV series Star Trek, the Borg are cybernetic aliens that assimilate humans and other creatures as a means of achieving perfection. So when Jill Banfield, a geomicrobiologist at the University of California, Berkeley, sifted through DNA in the mud of her backyard and discovered a strange linear chromosome that included genes from a variety of microbes, her Trekkie son proposed naming it after the sci-fi aliens. 

The new type of genetic material was a mystery. Maybe it was part of a viral genome. Maybe it was a strange bacterium. Or maybe it was just an independent piece of DNA existing outside of cells. Whatever it is, it's "pretty exciting," says W. Ford Doolittle, an evolutionary biologist at Dalhousie University who was not involved with the work.

Researchers have found many examples of DNA floating independently outside the chromosome or chromosomes that make up an organism's standard genome. Small loops called plasmids, for example, exist inside microbes and ferry genes for thwarting antibiotics among different kinds of bacteria.

But Banfield wasn't looking for DNA that could move between organisms. Instead, she and graduate student Basem Al-Shayeb were searching for viruses that infect archaea, a type of microbe often found in places devoid of oxygen. 

They would dig 1 meter or more below the surface and collect mud samples that might harbor archaea and their viruses. Next, they would sequence every stretch of DNA in the samples and use sophisticated computer programs to scan for sequences that signified a virus, rather than any other organism.

"We started off with a piece of mud and 10 trillion pieces of DNA," Banfield says. One sample, taken from the mud on her property, contained a gene-filled stretch of DNA almost 1 million bases long—and more than half the genes were novel. 

This linear stretch of DNA also had a particular pattern of bases at its beginning and end, distinct stretches of repetitive DNA between its genes, and two places along the sequence where DNA duplication could begin—which indicated the Borg could make copies of itself. Together, this suggested it was not just a random concoction of genes.

After they identified the first Borg sequence, the researchers began to scan microbial DNA in public databases to see whether they could find anything similar. They found a few variations in groundwater from Colorado—there, the first purported Borg showed up about 1 meter deep and got more abundant deeper down. 

Other versions showed up in DNA from the discharge of an abandoned mercury mine in Napa, California, and from a shallow riverbed of the East River in Colorado.

Altogether, the researchers isolated 23 sequences they think may be Borgs—and 19 they have identified as having all the characteristics of the first Borg they discovered, they write this week on the preprint server bioRxiv. 

Some are almost 1 million bases long. "I don't think anything else that's been discovered is as big as these guys are," among previously known extrachromosomal DNA elements, Doolittle says.  READ MORE...

DNA Analysis of Micronesians

Micronesia is defined as a country and has been a much-ballyhooed friend in need for Israel at the United Nations. It actually consists of roughly 2,000 small islands spread over a vast region in the Pacific. 

Micronesia should not to be confused with the neighboring nations of Polynesia or Melanesia, which also consist of small islands in the Pacific. Now, a new study casts light on the origin of early Micronesians and it is more complicated than had been assumed.

It had been thought that Micronesians shared origins with southwest Pacific peoples, and that Micronesians likely stemmed from a single origin. 

Now, analysis of ancient and modern Micronesian DNA has detected five separate waves of migration to Micronesia in antiquity: three streams from eastern Asia, one from Polynesia, and one of people related to mainland Papua New Guineans, Yue-Chen Liu and David Reich of Harvard Medical School reported with colleagues last week in Science.

The three streams of “first remote Oceanian” migration into Micronesia included a previously unknown lineage, the team adds.

The study is based on genomic analysis of 164 people who lived 2,800 to 500 years ago at five sites around Micronesia, and 112 genomes of present-day people from the same areas.  READ MORE...

Sea Corals An Anti-Cancer Compound

 

Researchers find that sea corals are a source of a sought-after “anti-cancer” compound

The ocean floor is riddled with mysteries, but scientists have just discovered one of its best-kept secrets. For the last 25 years, researchers have been looking for the source of a natural chemical that has shown promise in preliminary studies for treating cancer. Now, researchers at the University of Utah Health report that easy-to-find soft corals—flexible corals that resemble underwater plants—make the elusive compound.

After determining the source, the researchers went on to discover the animal’s DNA code for synthesizing the chemical. They were able to carry out the initial stages of re-creating the soft coral chemical in the laboratory by following those directions.

“This is the first time we have been able to do this with any drug lead on Earth,” says Eric Schmidt, Ph.D., professor of medicinal chemistry at the University of Utah Health. He led the study with Paul Scesa, Ph.D., postdoctoral scientist and first author, and Zhenjian Lin, Ph.D., assistant research professor.

The breakthrough opens the door to generating the compound in big enough quantities for rigorous testing, which could one day result in a new cancer-fighting tool.  READ MORE...

Ancient Black Death Mystery

Researchers believe they may have found ground zero for the deadliest plague in human history, the Black Death — pulling the veil off a mystery that has been shrouded for nearly 700 years.

A paper published in Nature on Wednesday details how a team of archaeologists and geneticists sequenced the genome of plague bacteria found in medieval corpses that predate the first plague outbreaks in Eurasia. The make-up of this ancient bacterial DNA has led researchers to believe it was the origin for almost all subsequent strains of bubonic plague.

Samples of this original Yersinia pestis bacteria, the pathogen that causes bubonic plague, were found in northern Kyrgyzstan, in villages that were along the old Silk Road trade route in Central Asia.

The study began several years ago when Philip Slavin, an economic and environmental historian for the University of Stirling, came across records that a pair of 14th-century cemeteries had a significant amount of tombstones dated from 1338 to 1339. Ten of these tombstones explicitly referenced pestilence.

This was unusual because, prior to this study, the earliest deaths associated with the plague were in 1346 in the Crimean Peninsula.

“When you have one or two years with excess mortality, it means something funny is going on there,” Slavin said at a news conference.  READ MORE...

Causes of Cancer

A team of researchers led by Yale University scientists can now quantify the factors causing changes in the DNA that contribute most to cancer growth in tumors of most major tumor types.

In a new paper published in the journal Molecular Biology and Evolution, they say that their new molecular analysis approach clarifies a long-standing debate about how much control humans have over cancer development over time.

Looking at the instances of specific genetic mutations can reveal the extent to which preventable exposures like ultraviolet light caused tumor growth in 24 cancers, said Jeffrey Townsend, Ph.D., the Elihu Professor of Biostatistics in the Department of Biostatistics at Yale School of Public Health (YSPH).


“We can now answer the question — to the best of our knowledge — ‘What is the underlying source of the key mutations that changed those cells to become a cancer instead of remaining normal tissue?’” he said.

Some of the most common cancers in the United States are known to be highly preventable by human decisions. Skin cancers, such as melanoma, emerge in large part because of prolonged exposure to ultraviolet light, and lung cancers can often be traced back to tobacco use. But scientists have long struggled to gauge how much any individual’s tumor developed as a result of preventable actions versus aging or “chance.”  READ MORE...

Grave For Men Holds Woman

Scientists tested the ancient DNA of 14 people interred at the monumental cemetery at

Li: Pascal Radigue; CC BY 4.0)

ve

The mysterious 6,500-year-old burial of a woman and several arrowheads in northern France may reveal details of how women were regarded in that society during the Neolithic period, or New Stone Age, a new study finds.


The researchers investigated giant graves known as "long barrows" — large earthen mounds, often hundreds of feet long and sometimes retained by wooden palisades that have since rotted away. Of the 19 human burials in the Neolithic cemetery at Fleury-sur-Orne in Normandy, the team analyzed the DNA of 14 individuals; but only one was female.


The woman was buried with "symbolically male" arrows in her grave, and the researchers argue that she may have had to be regarded as "symbolically male" to be buried there.

"We believe that these male-gendered artefacts place her beyond her biological sexual identity," said study lead author Maïté Rivollat, an archaeologist and geneticist at the University of Bordeaux. "This implies that the embodiment of the male sex in death was necessary for her to gain access to burial in these giga Dntic structures."

Archaeologists attribute the barrows at Fleury-sur-Orne to the Neolithic Cerny culture. Several other Cerny cemeteries have been found hundreds of miles away in the Paris Basin region to the southeast, but Fleury-sur-Orne is the largest yet found in Normandy.  READ MORE...

Living to 150

Humans could live until the ripe old age of 150 years according to recent research – and scientists are racing to work out how.

Harvard geniuses, biohackers and internet billionaires are all looking for ways that humans can crack the code on aging.

WaitButWhy blogger Tim Urban writes “the human body seems programmed to shut itself down somewhere around the century mark, if it hasn’t already”.

And Urban is right! There are no verified cases of a person living to be older than 122, though the oldest living person is on their way at age 119.

Researchers at GERO.AI concluded the “absolute limit” of the human lifespan to be between 100 and 150 – they came to this conclusion by analyzing 70,000 participants up to age 85 based on their ability to fight disease, risk of heart conditions and cognitive impairment.

The Conversation reported that not a single participant showed the biological resiliency to live to 150 – but notes the study is limited by today’s medical standards.

Will improvements in medicine, environment and technology to drastically lengthen the average lifespan and make 150 a reality?

Humans could live until the age of 150, according to a new study.  Shutterstock  Brutal biology

The human body is made up of about 30 trillion cells. Cells are constantly dying and being replaced by replicants.

Within the cell body there are chromosomes – these are DNA strands with the code written for humans within them.

At the end of a DNA strand is a microscopic bundle of non-crucial DNA, so that none of the important stuff gets snipped off when the cell divides.

A cell can divide itself about 50 times before it’s lost its ability to replicate.

As more and more cells become ineffective and die, the signs of aging start to show in gray hair, weaker bones and vision loss.

Some theorize this process can be stopped or reversed.  READ MORE...

Matching Drugs to DNA

We have the technology to start a new era in medicine by precisely matching drugs to people's genetic code, a major report says.

Some drugs are completely ineffective or become deadly because of subtle differences in how our bodies function.

The British Pharmacological Society and the Royal College of Physicians say a genetic test can predict how well drugs work in your body.

The tests could be available on the NHS next year.

Your genetic code or DNA is an instruction manual for how your body operates. The field of matching drugs to your DNA is known as pharmacogenomics.

It would have helped Jane Burns, from Liverpool, who lost two-thirds of her skin when she reacted badly to a new epilepsy drug.

She was put on carbamazepine when she was 19. Two weeks later, she developed a rash and her parents took her to A&E when she had a raging fever and began hallucinating.

The skin damage started the next morning. Jane told the BBC: "I remember waking up and I was just covered in blisters, it was like something out of a horror film, it was like I'd been on fire."

Her epilepsy medicine caused Stevens-Johnson syndrome, which affects the skin and is far more likely to happen in people who are born with specific mutations in their genetic code.

Mrs. Burns says she was "extremely, extremely lucky" and said she supports pharmacogenomic tests.

"If it saves your life, then it's a fantastic thing."      READ MORE...

A Stoneage Woman

Oscar Nilsson, a forensic artist based in Sweden, spent 350 hours reconstructing the Stone Age woman's likeness. (Image credit: Oscar Nilsson )



A Stone Age woman who lived 4,000 years ago is leaning on her walking stick and looking ahead as a spirited young boy bursts into a run, in a stunning life-size reconstruction now on display in Sweden.


Although her likeness is new — it debuted last month in an exhibit about ancient people at Västernorrlands Museum — researchers have known about this woman's existence for nearly a century. During the construction of a road in the hamlet of Lagmansören in 1923, workers found her skeletal remains buried next to the remains of a child, likely a 7-year-old boy.


"With our eyes and perhaps in all times, you tend to think that this is a mother and son," said Oscar Nilsson, the Sweden-based forensic artist who spent 350 hours creating the lifelike model. "They could be. Or they could be siblings: sister and brother. They could be relatives, or they could just be tribe friends. We don't know, because the DNA was not that well preserved to establish this relationship."


But as Nilsson molded the woman's posture and sculpted her face, he pretended that she was near her son who was scampering ahead of her. "She's looking with the mother's eyes — both with love and a bit of discipline," Nilsson told Live Science. This stern but tender gaze looks as if she's on the cusp of calling out to the boy, telling him to be careful.  READ MORE...

New Genetics Research

A photograph of the skeleton of one of the four individuals who we have sequenced who we think is likely to have participated in the migration we detect into southern Britain and to have displaced half the ancestry of the local population. This skeleton was excavated from the site of Cliffs End Farm in Kent. Credit: Wessex Archaeology

Two new studies highlight technological advances in large-scale genomics and open windows into the lives of ancient people.

New research reveals a major migration to the island of Great Britain 3,000 years ago and offers fresh insights into the languages spoken at the time, the ancestry of present-day England and Wales, and even ancient habits of dairy consumption.

The findings are described in Nature by a team of more than 200 international researchers led by Harvard geneticists David Reich and Nick Patterson. Michael Isakov, a Harvard undergraduate who discovered the existence of the migration, is one of the co-first authors.


This image is of bronze age tools from the National Museums of Scotland, which could give readers a sense of the material culture associated with people who lived at the time of the migration. Credit: Bronze Age tools curated the National Museums of Scotland

The analysis is one of two Reich-led studies of DNA data from ancient Britain that Nature published on Tuesday. Both highlight technological advances in large-scale genomics and open new windows into the lives of ancient people.

“This shows the power of large-scale genetic data in concert with archaeological and other data to get rich information about our past from a time before writing,” said Reich, a professor in the Department of Human Evolutionary Biology and a professor of genetics at Harvard Medical School. “The studies are not only important for Great Britain, where we now have far more ancient DNA data than in any other region, but also because of what they show about the promise of similar studies elsewhere in the world.”

The researchers analyzed the DNA of 793 newly reported individuals in the largest genome-wide study involving ancient humans. Their findings reveal a large-scale migration likely from somewhere in France to the southern part of Great Britain, or modern-day England and Wales, that eventually replaced about 50 percent of the ancestry of the island during the Late Bronze Age (1200 to 800 B.C.).

The study supports a recent theory that early Celtic languages came to Great Britain from France during the Late Bronze Age. It challenges two prominent theories: that the languages arrived hundreds of years later, in the Iron Age, or 1,500 years earlier at the dawn of the Bronze Age.  READ MORE...