Like treasured recipes passed down from generation to generation, there are just some regions of DNA that evolution doesn't dare tweak. Mammals far and wide share a variety of such encoded sequences, for example, which have remained untouched for millions of years.
Humans are a strange exception to this club. For some reason, recipes long preserved by our ancient ancestors were suddenly 'spiced up' within a short evolutionary period of time.
Because we're the only species in which these regions have been rewritten so rapidly, they are called 'human accelerated regions' (or HARs). What's more, scientists think at least some HARs could be behind many of the qualities that set humans apart from their close relatives, like chimpanzees and bonobos.
Led by computational biologist Katie Pollard, director of the Gladstone Institute of Data Science and Biotechnology in the US, a team of researchers identified HARs nearly two decades ago while comparing human and chimpanzee genomes.
In a new study, Pollard's team found the 3D folding of human DNA in the nucleus is a key factor in this pivotal moment for our species.
Imagine a length of DNA from our last common ancestor with chimpanzees as a long scarf wrapped around your neck, with stripes of various colors running across its weave down its entire length.
Now picture someone tried to make the exact same scarf, but they didn't quite follow the original pattern. Some of the stripes are narrower, some are wider, and some feature colors in a different order than the original. READ MORE...
