Showing posts with label National Institute of Health. Show all posts
Showing posts with label National Institute of Health. Show all posts
Friday, March 3
Searching for Missing Genomes
Enormous strides have been made to unravel the secrets of the human genome, so why are we missing the genetic information of most of the planet?
In the summer of 2020, a 63-year-old African American woman with colon cancer was treated with a common chemotherapy known as fluoropyrimidines at the National Institutes of Health (NIH) Clinical Centre in Bethesda, Maryland. But over the coming weeks, she began to develop a severe side-effect known as pancytopenia – a rapid and sudden decrease of red and white blood cells and platelets – causing her to be rushed into intensive care.
This kind of reaction is surprisingly common. Around 38,000 cancer patients in England and approximately 154,000 patients in the US are initiated on fluoropyrimidine-based treatments every year. While fluoropyrimidines help save lives, between 20% and 30% of the people who receive these drugs require lower doses, because their bodies struggle to process them. If given the standard dose, they experience reactions which can vary from severe to fatal.
Like many adverse drug reactions, this is thought to be at least in part due to variations in the human genome, the strings of billions of letters or chemical bases which comprise our DNA. But while all humans share 99.9% of our genome, the remaining 0.1% varies markedly from one individual to another, or between ethnic groups. Differences in the underlying sequence behind a particular gene – which can be anything from a few hundred to several million bases – can have profound and far-reaching consequences for our health.
In recent years, genetic-sequencing studies have started to get to the bottom of why some people react so badly to fluoropyrimidines, pinpointing four different variations of a gene called DPYD which is involved in metabolism, as the likely cause. Healthcare systems around the world have now begun sequencing the DNA of certain cancer patients and screening for each of these four variants before determining their chemotherapy dose.
The only problem is that these studies were done entirely on white people, or as geneticists say, "individuals of European ancestry". While different variants of DPYD may serve as warning signs for people of other ethnicities, we do not have enough data to be sure of which variants are most applicable to different ethnic groups. "Ethnic minority patients will usually be given conventional doses of the drugs," says Munir Pirmohamed, a pharmacologist at the University of Liverpool in the UK. "Some of these patients will carry other ethnic-specific variants which also affect their ability to metabolise these drugs, but we do not currently genotype for those, largely because we do not know." READ MORE...
Monday, June 14
Taking Breaks
In a study of healthy volunteers, National Institutes of Health researchers have mapped out the brain activity that flows when we learn a new skill, such as playing a new song on the piano, and discovered why taking short breaks from practice is a key to learning.
The researchers found that during rest the volunteers’ brains rapidly and repeatedly replayed faster versions of the activity seen while they practiced typing a code. The more a volunteer replayed the activity the better they performed during subsequent practice sessions, suggesting rest strengthened memories.
“Our results support the idea that wakeful rest plays just as important a role as practice in learning a new skill. It appears to be the period when our brains compress and consolidate memories of what we just practiced,” said Leonardo G. Cohen, M.D., senior investigator at the NIH’s National Institute of Neurological Disorders and Stroke (NINDS) and the senior author of the study published in Cell Reports.
“Understanding this role of neural replay may not only help shape how we learn new skills but also how we help patients recover skills lost after neurological injury like stroke.”
The study was conducted at the NIH Clinical Center. Dr. Cohen’s team used a highly sensitive scanning technique, called magnetoencephalography, to record the brain waves of 33 healthy, right-handed volunteers as they learned to type a five-digit test code with their left hands. The subjects sat in a chair and under the scanner’s long, cone-shaped cap. TO READ MORE, CLICK HERE...
The researchers found that during rest the volunteers’ brains rapidly and repeatedly replayed faster versions of the activity seen while they practiced typing a code. The more a volunteer replayed the activity the better they performed during subsequent practice sessions, suggesting rest strengthened memories.
“Our results support the idea that wakeful rest plays just as important a role as practice in learning a new skill. It appears to be the period when our brains compress and consolidate memories of what we just practiced,” said Leonardo G. Cohen, M.D., senior investigator at the NIH’s National Institute of Neurological Disorders and Stroke (NINDS) and the senior author of the study published in Cell Reports.
“Understanding this role of neural replay may not only help shape how we learn new skills but also how we help patients recover skills lost after neurological injury like stroke.”
The study was conducted at the NIH Clinical Center. Dr. Cohen’s team used a highly sensitive scanning technique, called magnetoencephalography, to record the brain waves of 33 healthy, right-handed volunteers as they learned to type a five-digit test code with their left hands. The subjects sat in a chair and under the scanner’s long, cone-shaped cap. TO READ MORE, CLICK HERE...
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