Gene That Makes Muscles Stronger

The study found that the gene promotes muscle strength during exercise.

Researchers have discovered a gene that increases muscle strength when activated by exercise, opening the door to the creation of therapeutic treatments that replicate some of the benefits of working out.

The University of Melbourne-led research, which was published in Cell Metabolism, demonstrated how various forms of exercise alter the molecules in our muscles and led to the identification of the new C18ORF25 gene, which is activated by all forms of exercise and is responsible for enhancing muscle strength. Animals lacking C18ORF25 have weaker muscles and worse exercise performance.

Dr. Benjamin Parker, project leader, said that by activating the C18ORF25 gene, the research team could observe muscles grow significantly stronger without necessarily becoming larger.


“Identifying this gene may impact how we manage healthy aging, diseases of muscle atrophy, sports science, and even livestock and meat production. This is because promoting optimal muscle function is one of the best predictors of overall health,” Dr. Parker said.

“We know exercise can prevent and treat chronic diseases including diabetes, cardiovascular disease, and many cancers. Now, we hope that by better understanding how different types of exercise elicit these health-promoting effects at the molecular level, the field can work towards making new and improved treatment options available.”  READ MORE...