Galileo Manuscript for the 17th-Century

For more than 80 years, a manuscript drafted by Galileo Galilei was considered “one of the great treasures” of the University of Michigan’s library. That is, until recently, when an expert on the 17th-century astronomer discovered that the document is a 20th-century fake.

Acquired by the school in 1938, the top half of the single-leaf letter finds Galileo reflecting on the potential uses of a telescope he built in 1609. On the lower part, the Italian scientist demonstrates one of the first observations he made with the instrument: glowing objects around Jupiter that appeared to move position nightly—the planet’s moons.

Galileo’s revelation would, in due time, have profound implications on our understanding of the universe. And the document, according to the university, was thought to be among the first pieces of “observational data that showed objects orbiting a body other than the earth.”

But in May, Georgia State University historian Nick Wilding made his own important observation: the Galileo letter had a few suspicious peculiarities.

The researcher, who is working on a book about Galileo, found there was no record of the manuscript in Italian archives. In fact, there was no record of the document at all before 1934, when it was acquired at auction by a Detroit businessman. (The owner donated the letter to the university upon his death, four years later.)

Wilding also noticed that, even though the two sections of the letter were written months apart, the ink appeared consistent across both.

“It just kind of jumps out as weird,” he told the New York Times this week. “This is supposedly two different documents that happen to be on one sheet of paper. Why is it all exactly the same color brown?”

The catalogue for the auction at which the manuscript first appeared further inspired doubt in the historian’s mind. It claimed that a former archbishop of Pisa had authenticated the letter by comparing it to two other Galileo documents that had been given to him by Tobia Nicotra—an infamous counterfeiter from Milan.

Wilding reached out to the University of Michigan library with his evidence, and after conducting its own investigation into the provenance of the piece, the institution came to the same conclusion: The manuscript was a forgery. The school announced the news this week.  READ MORE...

Where Do Our Minds Go?

After experimenting on a hen, his dog, his goldfish, and himself, dentist William Morton was ready. On Oct. 16, 1846, he hurried to the Massachusetts General Hospital surgical theater for what would be the first successful public test of a general anesthetic.

His concoction of sulfuric ether and oil from an orange (just for the fragrance) knocked a young man unconscious while a surgeon cut a tumor from his neck. To the onlooking students and clinicians, it was like a miracle. 

Some alchemical reaction between the ether and the man’s brain allowed him to slip into a state akin to light sleep, to undergo what should have been a painful surgery with little discomfort, and then to return to himself with only a hazy memory of the experience.

Monitoring patients’ brains still isn’t something that medical boards require.

General anesthesia redefined surgery and medicine, but over a century later it still carries significant risks. Too much sedation can lead to neurocognitive disorders and may even shorten lifespan; too little can lead to traumatic and painful wakefulness during surgery. 

So far, scientists have learned that, generally speaking, anesthetic drugs render people unconscious by altering how parts of the brain communicate. But they still don’t fully understand why. Although anesthesia works primarily on the brain, anesthesiologists do not regularly monitor the brain when they put patients under. 

And it is only in the past decade that neuroscientists interested in altered states of consciousness have begun taking advantage of anesthesia as a research tool. “It’s the central irony,” of anesthesiology, says George Mashour, a University of Michigan neuroanesthesiologist, whose work entails keeping patients unconscious during neurosurgery and providing appropriate pain management.

Mashour is one of a small set of clinicians and scientists trying to change that. They are increasingly bringing the tools of neuroscience into the operating room to track the brain activity of patients, and testing out anesthesia on healthy study participants. 

These pioneers aim to learn how to more safely anesthetize their patients, tailoring the dose to individual patients and adjusting during surgery. They also want to better understand what governs the transitions between states of consciousness and even hope to crack the code of coma.  READ MORE...

Human Gut Microbiota

Have you heard about the food additive E415? It is also known as xanthan gum. Most likely, you eat it several times a week. Xanthan gum is used in everyday foods such as baked goods, ice cream and salad dressings. The additive is also widely used as a substitute for gluten in gluten-free foods.

New research now shows that xanthan gum affects our gut microbiota.

The study was recently published in Nature Microbiology by a team of scientists at NMBU in collaboration with the University of Michigan and several other international partners.

"We were surprised at how much the human gut bacteria have adapted to this additive since it was introduced into the modern diet only fifty years ago," says NMBU researcher Sabina Leanti La Rosa (above).

When it was first introduced, xanthan gum was thought to not affect us as it was not digested by the human body. However, the new study shows that the additive nevertheless affects the bacteria that live in our intestines. And these bacteria are important for our health and well-being.

"The gut bacteria we have investigated show genetic changes and a rapid adaptation to enable them to digest this particular additive," explains professor Phil Pope.

He leads the Microbial Ecology and Meta-Omics group at NMBU, where the researchers who conducted the new study work.  READ MORE...

Top Problem is INFLATION Since 1985

The share of Americans who rate inflation as the top issue facing the country is at the highest in nearly 40 years, according to a Gallup poll released Tuesday.

About one in five Americans, or 17%, surveyed March 1-18 cited inflation as the nation’s most important problem. That’s up from 10% in February, and compares with 4% who pointed to fuel prices in particular.

U.S. consumer prices are rising at the fastest pace in four decades, outpacing wage gains and fanned further by Russia’s war in Ukraine. Gas prices are near record highs -- well over $4 a gallon nationwide -- especially straining lower-income families.

Among those polled -- a little over 1,000 U.S. adults -- 22% say the government is the top problem outside of the economy, while 9% cited the war in Ukraine. The share citing the coronavirus fell to the lowest level since the pandemic began.

Similar to a University of Michigan survey -- which showed U.S. consumer sentiment remained at a decade low in March -- inflation concerns diverge sharply from a political perspective. Nearly 80% of Republicans are worried about inflation, more than double the proportion of Democrats, according to Gallup.   SOURCE:  Bloomberg      READ MORE...