Link Between Math & Genes

Researchers have discovered an unexpected link between number theory in mathematics and genetics, providing critical insight into the nature of neutral mutations and the evolution of organisms. The team found the maximal robustness of mutations—mutations that can occur without changing an organism’s characteristics—is proportional to the logarithm of all possible sequences that map to a phenotype, with a correction provided by the sums-of-digits function from number theory.


An interdisciplinary team of mathematicians, engineers, physicists, and medical scientists has discovered a surprising connection between pure mathematics and genetics. ThAnd yet, again and again, number theory finds unexpected applications in science and engineering, from leaf angles that (almost) universally follow the Fibonacci sequence, to modern encryption techniques based on factoring prime numbers. Now, researchers have demonstrated an unexpected link between number theory and evolutionary genetics.

Specifically, the team of researchers (from Oxford, Harvard, Cambridge, GUST, MIT, Imperial, and the Alan Turing Institute) have discovered a deep connection between the sums-of-digits function from number theory and a key quantity in genetics, the phenotype mutational robustness. This quality is defined as the average probability that a point mutation does not change a phenotype (a characteristic of an organism).

The discovery may have important implications for evolutionary genetics. Many genetic mutations are neutral, meaning that they can slowly accumulate over time without affecting the viability of the phenotype. These neutral mutations cause genome sequences to change at a steady rate over time. Because this rate is known, scientists can compare the percentage difference in the sequence between two organisms and infer when their latest common ancestor lived.is connection sheds light on the structure of neutral mutations and the evolution of organisms.

Number theory, the study of the properties of positive integers, is perhaps the purest form of mathematics. At first sight, it may seem far too abstract to apply to the natural world. In fact, the influential American number theorist Leonard Dickson wrote “Thank God that number theory is unsullied by any application.”     READ MORE...

Reverse Aging Process

Behind Bryan Johnson’s (pictured) $2 million anti-aging regimen is 29-year-old doctor Oliver Zolman.



Tech CEO Bryan Johnson’s rigid routine of 1,977 vegan-based calories a day, a couple dozen morning supplements, and consistent organ testing caught the attention of the masses ever since he first shared his reverse-aging protocol with Bloomberg in January. 

The 45-year-old’s quest for immortality has garnered massive criticism from longevity experts and doctors who question whether his dedication will prove anything long term, not to mention the impact it may have on his quality of life.

Pulling the strings behind Johnson’s reportedly $2 million longevity craze is a team of 30-plus doctors and health experts, led by 29-year-old Oliver Zolman—a millennial doctor obsessed with turning back the clock.

“I’m going for results that have never been achieved ever,” Zolman tells Fortune. “My bar is very high.” Zolman juggles about 10 clients at a time and reportedly charges upwards of $1,000 an hour for intensive age-related testing, according to Bloomberg’s profile. 

Zolman did not share his current rate with Fortune, but says he charges people based on their net worth.  “If they have no money, then I just don’t charge,” he says. “If they’re a billionaire, then it’s like, ‘Okay, thousands of dollars is nothing to them.’” 

Still, Zolman says most of his clients are similar to “Bryan’s demographic,” with some exceptions. But in a follow-up email, Zolman said he does not charge anyone except for Johnson and “never actually charged $1,000 an hour.”

Zolman, who lives in Cambridge, England (but also spends time in Spain and hopes to open a clinic there), introduced himself as a “professional evidence-based rejuvenation coach and clinician trainer” at a lecture during the Longevity Summit Dublin last year.

“Rejuvenation just means getting younger, or making it younger so obviously to prove that, in an evidence-based way, you have to measure the age of something,” he says, adding that he measures individual ages of organs to determine protocols for clients. “You can’t just randomly say I feel younger. That’s completely ridiculous.”

Zolman has been fascinated with longevity and regenerative medicine—modalities that aim to combat age-related changes—since he was young.  READ MORE...

Making Skin Cells 30 Years Younger

Stock photo of fibroblasts (skin cells) labeled with fluorescent dyes. 

(Image credit: iStock / Getty Images Plus)

Researchers in the U.K. have developed a way to reverse the aging process in skin cells, turning back the biological clock by about 30 years.


De-aging cells has become increasingly common in the last decade, with researchers reprogramming multiple mouse, rat and human cell types. But never before have cells been de-aged by so many years and still retained their specific type and function.


The method, developed by Diljeet Gill, a postdoctoral candidate at the Babraham Institute in Cambridge, and his colleagues, was published April 8 in the journal eLife, and has been dubbed "maturation phase transient reprogramming."


The researchers applied this technique to fibroblasts (a common type of skin cell) from three middle-aged donors — who averaged at about 50 years old — then compared them to younger cells from donors aged 20 to 22. The researchers found that the middle-aged cells were similar to the younger cells, both chemically and genetically. When explored further, the team even noticed that the technique had affected genes related to age-related diseases, like Alzheimer's disease and cataracts.

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In addition, Gill and his colleagues looked at the behavior of the fibroblasts to determine if they could also act like younger skin cells. When they wounded a layer of the cells, they found that the rejuvenated cells quickly moved to fill the gap — the same way that younger cells behave when healing wounds.


This study is not the first to de-age skin cells. That title goes to Nobel prize winner Shinya Yamanaka, who genetically reprogrammed mouse skin cells and turned them into so-called induced pluripotent stem cells, or iPSCs, back in 2006. These iPSCs resemble cells in early development, and have the potential to form any cell type in the body.  READ MORE...

A New Force

Harry Cliff, a Cambridge particle physicist writes...

After years without particle physics making the news, recent announcements suggest a breakthrough. Could a new fundamental force also explain the mystery of the three generations of matter? Harry Cliff weighs up the case.

Most of my colleagues would probably admit, at least in private, that it’s been an anxious time to be a particle physicist. Thirteen years ago, when the world’s largest (and most expensive) scientific instrument, the Large Hadron Collider (LHC), fired up for the first time, hopes were high that we would soon discover new particles and forces that could help address some of the most profound mysteries in science.

Things got off to a spectacular start with the discovery of the long-sought Higgs boson in 2012, but momentous as its discovery was, the Higgs belongs to the well-established ‘standard model’ of particle physics, which took shape more than half a century ago in the 1960s and 70s. Now, I don’t want to do the standard model down. It is without a doubt the most successful scientific theory ever devised, describing everything we know about the fundamental building blocks that makes up the world around us with stunning precision. You could make a good case for it being the greatest intellectual achievement of humankind. But we know it can’t be the end of the story.

The standard model has no solutions for numerous thorny problems, including how matter survived annihilation during the Big Bang, or indeed why we observe the set of particles that we do. Perhaps its most glaring omission is its failure to account for a whopping 95% of universe, which astronomy tells us is dominated by enigmatic substances known as dark matter and dark energy. So, when the LHC switched on in September 2008, particle physicists like me were itching to see something altogether new, something that might show us the way to an expanded picture of the subatomic world.

Yet almost a decade later, after literally thousands of searches performed by the four big LHC experiments, nature has stubbornly refused to give up its secrets. After the discovery of the Higgs, the LHC experiments continued to verify the predictions of the standard model, while ruling out a whole host of speculative new theories that were intended to extend it into new territory.

Some began to talk about a crisis in particle physics. Could it be that the long quest for an ever-deeper understanding of the fundamental constituents of our universe had reached a dead end? However, amid the gathering gloom, a series of unexpected chinks of light were beginning to appear.

Once again, particle physics made headline news around the world. Major discoveries seemed to be arriving like buses.

The LHCb experiment, one of the four giant detectors that study particle collisions produced by the LHC and the experiment on which I work, was reporting a growing number of ‘anomalies’; measurements that seemed to be in tension with the predictions of the standard model. While intriguing, for a long while these deviations were too subtle for physicists to have much confidence that they were anything other than random statistical wobbles in the data. That is until the 23rd March of this year.

On that day, my colleagues at LHCb announced they had found firm evidence for exotic particles known as beauty quarks decaying in ways that the standard model can’t explain. If borne out, these results suggest the existence of a brand-new force of nature, which would make it arguably the most momentous scientific discovery of the 21st century so far. The story broke out into the mainstream media, quickly making it one of the most widely covered particle physics stories since the discovery of the Higgs in 2012.

Then, just two weeks later on the 7th April, a completely different experiment at Fermilab in the United States announced a second result that seemed to suggest that fundamental particles called muons were also experiencing the tug of a hitherto undiscovered force. Once again, particle physics made headline news around the world. Major discoveries seemed to be arriving like buses.  READ MORE