Showing posts with label University of Liverpool. Show all posts
Showing posts with label University of Liverpool. Show all posts

Tuesday, October 24

Before Homo Sapiens Existed


Archaeologists from Europe and Africa have uncovered the oldest wood structure ever discovered, dating back almost half a million years — meaning an unknown species of hominins, predating us homo sapiens, was presumably responsible for its creation.

The researchers laid out their findings in a recent paper in the science journal Nature, where they reported that they had found the wood structure of "two interlocking logs joined transversely by an intentionally cut notch" at a site in Kalambo Falls, Zambia, and dated it to a distant 476,000 years ago. 

At the same location, which the scientists say was likely the foundation for a dwelling or platform, they also found four tools fashioned from wood: a digging stick, a cut log, a wedge, and notched branch, each also dating to before the time of modern humans.

"This find has changed how I think about our early ancestors," said University of Liverpool archaeology professor and the paper's lead author Larry Barham in a statement. "Forget the label ‘Stone Age,’ look at what these people were doing: they made something new, and large, from wood. 

They used their intelligence, imagination, and skills to create something they’d never seen before, something that had never previously existed."

Handy Man
The wood was preserved because Kalambo Falls kept the pieces permanently waterlogged, hence sealing them away from oxygen and oxygen-dependant bacteria that would degrade them

The finding is particularly significantbecause wood has rarely been preserved from the Early Stone Age — offering an ultra-rare peek into the lives of our distant ancestors.  READ MORE...

Saturday, May 14

Cancer Drug Toxicity

3D rendition of T cells attacking cancer cells. Credit: La Jolla Institute for Immunology



Researchers uncover a new strategy to avoid cancer immunotherapy side effects.  It’s not often that a failed clinical trial leads to a scientific breakthrough.


When patients in the UK started experiencing negative side effects during a cancer immunotherapy trial, researchers at La Jolla Institute for Immunology (LJI) Center for Cancer Immunotherapy and University of Liverpool went back, examined the data, and worked with patient samples to determine what went wrong.


Their findings, published today (May 4, 2022) in the journal Nature, provide critical clues to why many immunotherapies trigger dangerous side effects—and point to a more effective strategy for treating patients with solid tumors.


“This work shows the importance of learning from early stage clinical trials,” says La Jolla Institute for Immunology (LJI) Professor Pandurangan Vijayanand, M.D., Ph.D., who co-led the new research with Christian H. Ottensmeier, M.D., Ph.D., FRCP, a professor with the University of Liverpool, The Clatterbridge Cancer Centre NHS Foundation Trust, and adjunct professor at LJI.  READ MORE...