Brain Changes in Autism

According to new research, brain changes in autism are comprehensive throughout the cerebral cortex rather than just particular areas thought to affect social behavior and language




UCLA study is the most comprehensive effort ever to study how autism affects the brain at the molecular level.

Brain changes in autism are comprehensive throughout the cerebral cortex, not only confined to particular regions traditionally considered to affect language and social behavior. These are the findings of a new study, led by the University of California, Los Angeles (UCLA), which substantially refines scientists’ understanding of how autism spectrum disorder (ASD) progresses at the molecular level.


Published on November 2 in the journal Nature, the study represents a comprehensive effort to characterize ASD at the molecular level. Although neurological disorders like Parkinson’s disease and Alzheimer’s disease have well-defined pathologies, autism and other psychiatric disorders have had a lack of defining pathology. This had made it particularly difficult to develop more effective treatments.


The new study finds brain-wide changes in virtually all of the 11 cortical regions analyzed. This holds true regardless of whether they are higher critical association regions – those involved in functions such as reasoning, language, social cognition, and mental flexibility – or primary sensory regions.

“This work represents the culmination of more than a decade of work of many lab members, which was necessary to perform such a comprehensive analysis of the autism brain,” said study author Dr. Daniel Geschwind, the Gordon and Virginia MacDonald Distinguished Professor of Human Genetics, Neurology and Psychiatry at UCLA.  READ MORE...

Higher Emotional Awareness

 

Abstract

The tendency to reflect on the emotions of self and others is a key aspect of emotional awareness (EA)—a trait widely recognized as relevant to mental health. However, the degree to which EA draws on general reflective cognition vs. specialized socio-emotional mechanisms remains unclear. Based on a synthesis of work in neuroscience and psychology, we recently proposed that EA is best understood as a learned application of domain-general cognitive processes to socio-emotional information. In this paper, we report a study in which we tested this hypothesis in 448 (125 male) individuals who completed measures of EA and both general reflective cognition and socio-emotional performance. As predicted, we observed a significant relationship between EA measures and both general reflectiveness and socio-emotional measures, with the strongest contribution from measures of the general tendency to engage in effortful, reflective cognition. This is consistent with the hypothesis that EA corresponds to the application of general reflective cognitive processes to socio-emotional signals.

Introduction
Trait differences in emotional awareness (EA) have been the topic of a growing body of empirical work in psychology and psychiatry. Individuals with high EA report granular emotional experiences and perceive similar experiences in others, often promoting more adaptive social and emotional functioning (for a review, see1; for related work, see2). Current theoretical models posit that the tendency to consciously reflect on the emotions of self and others (e.g., their causes, associated sensations, and how they can be regulated) is a key aspect of EA3, as well as of related constructs such as emotional intelligence4,5,6,7 and alexithymia8,9,10. As measured by the Levels of Emotional Awareness Scale (LEAS;11,12), multiple studies suggest that EA is an important determinant of adaptive emotional functioning. High EA has been linked to emotion recognition abilities and openness to experience, among other adaptive skills11,13,14,15,16,17,18,19. Low EA has also been associated with multiple affective disorders20,21,22,23,24,25. The neurocognitive basis of EA is also an important question within both basic science and clinical research, with a growing number of studies on its developmental basis16,26,27 and neural correlates (e.g., for a review, see28; for more recent studies, see23,29,30,31,32,33,34,35,36,37).

One important unanswered question pertains to the degree to which the tendency to reflect on emotion in EA depends on domain-general reflective cognitive processes vs. specialized socio-emotional mechanisms. Some models make strong distinctions between emotional and cognitive processes and suggest that the brain contains specialized emotional mechanisms38,39; and some neuroscientific studies also suggest the presence of brain regions selectively engaged by social cognition40,41,42,43,44. In contrast, other cognitive and neural models suggest less separability between socio-emotional and cognitive process1,45,46,47,48,49. In a recent review50, we drew on work within evolutionary, developmental, and cognitive neuroscience to argue that EA may have an important dependence on domain-general cognitive processes. 

Specifically, EA appears to require holding emotional information in mind, integrating it with other available information in perception and memory, and using this information to reflectively plan adaptive courses of action (especially in social situations). While these abilities may be constrained by cognitive capacity (e.g., working memory span, IQ;32), it is suggested that trait differences in EA may further depend on the tendency to engage these reflective processes, independent of whether latent cognitive capacity is high or low. In this view, EA involves the application of effortful cognitive processes to emotion-related information (e.g., interoceptive information within oneself, facial, postural, and vocal cues in others, context cues, etc.), which may be facilitated during development by prepared learning and automatic attention biases toward socio-affective signals. The domain-general processes under discussion are “reflective” in the sense that they operate on mental contents in an integrative, slow, and deliberate manner—often reducing the chances of responding maladaptively in emotionally charged situations. However, the degree to which EA depends on domain-general reflective cognitive processes requires further empirical testing.  READ MORE...

A Relationship With Creativity

People under the influence of psilocybin — the active component of magic mushrooms — report having more profound and original thoughts, but tend to score lower on cognitive tests of creative ability, according to new research published in Translational Psychiatry. But the findings indicate that the psychedelic substance can still boost creative ability in the long-term.

The study also collected functional magnetic resonance imaging and proton magnetic resonance spectroscopy data, providing some new insights into the underlying neurobiological mechanisms associated with creative ability.

“Creativity is an essential cognitive ability linked to all areas of our everyday life, allowing us to adapt to an ever-changing environment and come up with ways to solve problems,” said lead researcher Natasha Mason (@NL_Mason), a PhD candidate at Maastricht University.

“Importantly, as well as being an essential process for everyday functioning, the (in)ability to think ‘outside of the box’ has also been associated with psychological disorders, such as depression and anxiety. These individuals can get stuck in maladaptive thought patterns, which can facilitate habitual (negative) behaviors. Thus, finding a way to enhance creativity is of broad interest.”

Scientists had found some preliminary evidence in the 1960s that the psychedelic drug LSD could enhance creative problem-solving. There was also some evidence that the psychedelic state induced by LSD could harm creative ability. But the issue has received little scientific attention since then.

“Over the years, a number of anecdotal reports have accumulated suggesting that the consumption of psychedelic drugs, like LSD and psilocybin, can enhance creativity,” Mason said. “Famous examples of psychedelic-affiliated creative breakthroughs include Kary Mullis’ discovery of the polymerase chain reaction, the 1960’s California-based computer industry, and the literary works of authors, such as Aldous Huxley and Ken Kesey. That said, although there are a large number of claims that psychedelics do this, no one has investigated this in a placebo-controlled experimental trial.”  READ MORE