Enamel Regeneration

Scientists have developed organoids from stem cells capable of producing dental enamel proteins. The research aims to use these advancements for dental treatments, including repairing damaged teeth or entirely regenerating lost ones.

This advance is viewed as a pivotal initial step toward innovative therapies for the repair and regeneration of teeth.

Stem cells have been used to produce organoids that release the proteins responsible for forming dental enamel, a substance that shields teeth from harm and decay. This initiative was led by a multi-disciplinary team of researchers from the University of Washington in Seattle.

“This is a critical first step to our long-term goal to develop stem cell-based treatments to repair damaged teeth and regenerate those that are lost,” said Hai Zhang, professor of restorative dentistry at the UW School of Dentistry and one of the co–authors of the paper describing the research.

The findings are published today in the journal Developmental Cell. Ammar Alghadeer, a graduate student in Hannele Ruohola-Baker’s laboratory in the Department of Biochemistry at the UW School of Medicine was the lead author on the paper. The lab is affiliated with the UW Medicine Institute for Stem Cell and Regenerative Medicine.

The researchers explained that tooth enamel protects teeth from the mechanical stresses incurred by chewing and helps them resist decay. It is the hardest tissue in the human body.

Enamel is made during tooth formation by specialized cells called ameloblasts. When tooth formation is complete, these cells die off. Consequently, the body has no way to repair or regenerate damaged enamel, and teeth can become prone to fractures or be subject to loss.     READ MORE...

Stimulating Hair Growth

A team at the University of California, Irvine, has identified a signaling molecule that 

potently stimulates hair growth.

SCUBE3 has been found to be a potential therapeutic option for treating androgenetic alopecia.

A signaling molecule known as SCUBE3, which was discovered by researchers at the University of California, Irvine, has the potential to cure androgenetic alopecia, a prevalent type of hair loss in both women and men.

The research, which was recently published in the journal Developmental Cell, uncovered the precise mechanism by which the dermal papilla cells, specialized signal-producing fibroblasts found at the bottom of each hair follicle, encourage new development. Although the critical role dermal papilla cells play in regulating hair growth is widely established, the genetic basis of the activating chemicals involved is little understood.

“At different times during the hair follicle life cycle, the very same dermal papilla cells can send signals that either keep follicles dormant or trigger new hair growth,” said Maksim Plikus, Ph.D., UCI professor of developmental & cell biology and the study’s corresponding author.

“We revealed that the SCUBE3 signaling molecule, which dermal papilla cells produce naturally, is the messenger used to ‘tell’ the neighboring hair stem cells to start dividing, which heralds the onset of new hair growth.”


For mice and humans to effectively develop hair, the dermal papilla cells must produce activating chemicals. Dermal papilla cells malfunction in people with androgenetic alopecia, drastically lowering the typically plentiful activating chemicals. 

For this study, a mouse model with excessive hair and hyperactivated dermal papilla cells was created. This model will help researchers learn more about the regulation of hair growth.  READ MORE...